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Layering is easy with a long necklace and this silver beauty adds sparkle to any outfit! Measuring a generous 26 inches long, this necklace is created with silver cracked glass beads surrounded by antique silver bead caps and finished with crystals, set at intervals around the entire necklace. The necklace is finished with a barrel clasp. Your necklace will ship in a gift box similar to the one pictured.
Molecular pathway of estrogen receptor (ER) action. Typically, estrogen binds to the ligand-binding domain of receptors in the nucleus, which causes a conformational change. Estrogen-responsive elements (ERE) mediate genomic effects. RE, response element; TF, transcription factor; GF, growth factor; GF-R, growth factor receptor; CoA, co-activator; CoR, co-repressor; MAPK, mictogen-activated protein kinase; PI3K, phophoinositide 3-kinase; Src, proto-oncogene tyrosine-protein kinase; AP-1, activating protein-1; Sp-1, stimulating protein-1. Adapted from Nie et al.16
Measurement parameters utilized to determine the esophageal motor function. (A) Esophagogastric junction (EGJ). (B) Esophageal body. EGJ-CI, esophagogastric junction-contractile integral; IRP, integrated relaxation pressure; LES, lower esophageal sphincter.
High-resolution manometry test swallows and maneuvers. (A) Supine 5 mL liquid; (B) upright 5 mL liquid; (C) viscous (apple sauce); (D) solid (graham cracker); (E) multiple rapid swallow; and (F) rapid drink challenge. Integrated relaxation pressure (IRP) and distal contractile integral (DCI) were 11 mmHg and 1760 mmHg·cm·sec (A), 8 mmHg and 1950 mmHg·cm·sec (B), 7 mmHg and 1600 mmHg·cm·sec (C), 10 mmHg and 1400 mmHg·cm·sec (D), 4 mmHg and 4600 mmHg·cm·sec (E), and 3 mmHg and 0 mmHg·cm·sec (F), respectively. Figure used with permission from the Esophageal Center at Northwestern.
Our diagnostic algorithm of defecation disorders using a colonic transit study. DD, defecation disorders; DRE, digital rectal examination; NTC, normal transit constipation; STC, slow transit constipation; RS, rectosigmoid colon.
Statistical maps showing voxel-mirrored homotopic connectivity (VMHC) differences between irritable bowel syndrome (IBS) and healthy controls (HCs;